Earth Picked (beta)

METHYLCHLOROISOTHIAZOLINONE

Functions: Preservative

allergy
May cause allergies

cacner
May cause cancer

restricted
Restricted in some regions

Description

About METHYLCHLOROISOTHIAZOLINONE: Methylchloroisothiazolinone is a widely-used preservative; has been associated with allergic reactions.

References

  • Chang MW, Nakrani R. 2014. Six children with allergic contact dermatitis to methylisothiazolinone in wet wipes (baby wipes). Pediatrics. 133(2):e434-8.
  • Connor TH, Tee PG, Afshar M, Connor KM. 1996. Mutagenicity of cosmetic products containing Kathon. Environmental and molecular mutagenesis 28(2), 127-32.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • European SCCS. 2009. Opinion on the mixture of 5-chloro-2-methylisothiazolin-3(2H)-one and 2-methylisothiazolin-3(2H)-one. SCCS/1238/09. December 2009. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_009.pdf
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Lundov MD, T Krongaard, T L Menné & J D Johansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
  • NIOSH (Cook CK, Friedman D). 1996. Health Hazard Evaluation Report, HEA 94–0402–2573. National Institute for Occupational Health and Safety.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.; Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992.
  • U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.